ABSTRACT
Tribulus terrestris extracts were prepared using solvents of different polarities and their irritant inducing effects were assessed in vivo on rabbit's ears
The result indicates that the polar components were in higher yield than the others and amounts of the extracted material were directly proportional to the polarities of solvents. Preliminary phytochemical screening shows diversity of compounds and comparative TLC analytical behaviour further indicated the resolution of mostly five compounds from the non-polar, intermediate polar and highly polar materials by different solvent systems. Irritant potency of water extract was assessed on rabbit's ears using a known method that was proved to be the most potent irritant [with +++ response, propagated in an area of 2.70 cm[2] diameter]